The benefits of Agmatine include enhanced muscle pumps, more effective nutrient transport, improved nutrient partitioning (greater number of calories shunted towards muscle
tissue and less stored in fat cells), increased blood flow, and greater production of luteinizing hormone and growth hormone. Agmatine appears to boost muscle pumps in various
Agmatine may enhance nutrient partitioning, which leads to more muscle glycogen (carbohydrates stored in muscle tissues) stored, thus more water retained in the muscle. This can lead to a “fuller” look to the muscle and enhanced muscle pumps.*
Agmatine appears to increase NO production by playing a competitive inhibitor role of the enzyme nitric oxide synthase. The nutrient partitioning effects of Agmatine may be due to its potential ability to increase the insulin response to carbohydrates, as well as the increased blood flow to the muscle seen with increased nitric oxide production. Agmatine may play a potential role in the hypothalamic control of luteinizing hormone (LH), thusly leading to increased levels of both hormones.
Agmatine enhances insulin production which elicits better insulin responses. Increased insulin response has been shown to have positive effects on body composition and musculature.
Agmatine contains antidepressant properties and anxiolytic (anxiety reliever) which can be beneficial in the heavy loading and high-stress life of a bodybuilder.
Agmatine acts on catecholamine release (Epinephrine > Norepinephrine > Dopamine). These endogenous compounds are utilized in almost every action throughout the human body. Specific to the athlete is the role in energy production and support in stress relief.
Agmatine offers potential assistance in kidney function via stimulation of the glomerular filtration rate (GFR). This can prep the bodybuilder as various nitrogenous waste products are eliminated through this system.
Agmatine serves as a potential aid in the recovery process of the athlete. It can also enhance the effects of analgesics required during recuperation from injury.
Agmatine stimulates GH and LH. In addition to the obvious effects on overall body composition, the stimulation of GH and LH levels can also be helpful in maintaining a healthy lifestyle as age sets in. The stimulation of pituitary hormones may also lead to stimulation of other various hormones such as IGF-1.
Agmatine modulates NO through a variety of mechanisms. It stimulates some types of nitric oxide synthase (NOS) while restraining others. This is crucial to the proper functioning of the polyamine biosynthetic pathways.
Specific to body composition, Agmatine has an independent role of testosterone and insulin management on lipid (fat) metabolism.
Agmatine offers antioxidant properties. This is of particular interest to the committed athlete. The load an athlete endures throughout a strict training regimen directly affects the free-radical buildup in the human body and can have damaging effects if the buildup continues. Agmatine can serve as a protection from these unwanted effects that free radicals propose to the body.
Agmatine acts as a novel neurotransmitter and can support a healthy mood. It can be beneficial to those looking to achieve a mental edge, whether it be in the gym or in everyday life.
Agmatine holds a hypotensive role which could assist the exogenously-enhanced athlete in regulating blood pressure.
As a result of these effects, supplementing any athletic and/or bodybuilding regimen with Agmatine may improve athletic performance, increase fat loss, and increase muscle size, vascularity, and fullness. Additional benefits including protection against free radical damage, antidepressant effects, and enhanced recovery mechanisms also add to the quality of everyday life. Arginine was the miracle worker of its time, but Agmatine appears to be an even better supplemental option in regards to body physique advancements and performance.